Postdoctoral researcher to develop antisense therapies for familial Alzheimer’s Disease

Job title:

Postdoctoral researcher to develop antisense therapies for familial Alzheimer’s Disease

Company

VIB

Job description

Description
The Laboratory for the Research of Neurodegenerative Diseases [https://destrooperlab.sites.vib.be/en] headed by prof. Bart De Strooper in collaboration with the Laboratory for Therapeutic and Diagnostic Antibodies [http://www.ltda.be/] headed by Prof. Maarten Dewilde, is looking for a motivated postdoctoral scientist to join our multidisciplinary project on gene therapy for Alzheimer’s Disease.
This work is focused on the specific targeting of clinical mutations that cause dominant inherited Alzheimer’s disease using a unique antisense strategy (ASO). We will couple those ASO to our proprietary blood-brain shuttles to improve brain exposure, improve administration via intravenous instead of intrathecal routes, and decrease toxicity associated with ASO treatment.
The candidate will be involved in both the generation and the testing of the ASO constructs and will follow the clinical candidates on their journey from preclinical to clinical application.
Additional information may be found in the following selected references:
De Strooper, B. & Karran, E. New precision medicine avenues to the prevention of Alzheimer’s disease from insights into the structure and function of gamma-secretases. EMBO J 43, 887-903 (2024).Rue, L. et al. Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics. Pharmaceutics 15 (2023).
Profile
Required
The successful candidate:
Should hold a PhD degree in neuroscience, biology, chemistry, engineering or a related fieldShould be creative, enthusiastic, critically thinking, and motivatedReady to work against stringent deadlinesEnjoys teamwork and has excellent oral and written communication skills in English.
Appreciated
Experience working with laboratory mice (FELASA B)
Project management and effective communication skills
Knowledge of the literature on neurodegenerative disorders
Good understanding of antisense oligonucleotide therapies
Interested in brain delivery of drugs
Good publication recordWe offfer
An exceptional strong scientific environment
Possibility to supervise students and technicians and develop an independent research profile
Access to state-of-the-art infrastructure
A stimulating, diverse international world-class research environment
Animal models, expertise in neurodegenerative disorders
Financial support is available for at least 2 years (renewable one year contract). However, the successful candidate is encouraged to obtain a personal fellowship (Marie-Curie, HFSP, EMBO, or National funding organizations).
Start date: as soon as possible – the position is available immediatelyHow to apply
Motivated candidates with a strong interest in neurodegeneration and with a strong commitment to basic research are invited to apply. Please complete the online application procedure and include a CV, a list of publications, a summary of past research and the contact information of 2 to 3 referees. The best-ranked candidates will be invited for an interview.
For additional information concerning this position, please contact Bart De Strooper (Bart.Destrooper@kuleuven.be [mailto:Bart.Destrooper@kuleuven.be] ) or Maarten De Wilde (maarten.dewilde@kuleuven.be)
Find out more about the De Strooper lab via this link [https://destrooperlab.sites.vib.be/en]
Find out more about the De Wilde via this link [https://gbiomed.kuleuven.be/english/research/50000715/52453312/]
Connect through our LinkedIn [https://www.linkedin.com/showcase/vib-ku-leuven-center-for-brain-and-disease-research/] page
Discover the Center by visiting the website [https://cbd.sites.vib.be/en] or looking around in our a virtual tour [https://360.cbd.vib.be/en]
Follow the Center on social media: Facebook [https://www.facebook.com/CenterforBrainandDiseaseResearch] , Instagram [https://www.instagram.com/cbd.research/] and X [https://x.com/CBD_VIB]
[https://x.com/CBD_VIB]

Expected salary

Location

Leuven, Vlaams Brabant

Job date

Fri, 25 Oct 2024 22:56:36 GMT

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