Principal Scientist Preclinical RD – Biophysics and Structural Bioinformatics

Job title:

Principal Scientist Preclinical RD – Biophysics and Structural Bioinformatics

Company

GlaxoSmithKline

Job description

Job PurposeCurrent developments in structural biology and related disciplines herald an exciting time in vaccine development. Technological advances enable us to identify antigen epitopes in detail, map these onto high resolution structures and apply this knowledge for structure based rational protein design. In this role, you will harness the combined power of state-of-the-art structural biology and in silico protein design tools to generate best-in-class vaccine antigens by leveraging GSK’s Global R&D organization capabilities.Key ResponsibilitiesScientific responsibilities

• Responsible for the conception, design, implementation, and interpretation of scientific research experiments in support of antigen structural characterization and vaccine development with emphasis on integrating a suite of biophysical approaches
• Contribute to Vaccine Ag candidate improvement with the particular focus on translating structure-function relationships into design approaches
• Contribute to the development and implementation of new technologies in the area of protein biophysics
• Contribute to Vx candidate design and Bioinformatic team alignment and maintenance of state of the art bioinformatics tools for Vaccine protein design
• Share expertise in multiple technical competency domains across the Belgium preclinical department and possibly across Scientific areas; continuous follow-up of key developments in own competency domain.
• Can advise discovery project and vaccine development leaders on scientific issues related to their projects
• Active participation and presentation of lab results in internal meetings, working groups and technical and project team meetings, ensuring quality interpretation and extensive quality check of raw data
• Can be the principal author of publications submitted to peer review journals
• Significant contribution (autonomous writing & review) to and direct interactions with the Regulatory/IP teams for the preparation of the preclinical section of Regulatory/IP documents, in own area of technical expertise.

Managerial responsibilities

• Ensure the adequate and timely translation of project milestones into laboratory activities
• May coordinate a team of scientist(s) and/or technician(s) involved in the completion of scientific experiment in scope of several projects; can supervise collaborative research studies with third parties but also PhD students or postdoc
• Ensure highest ethical standards, good scientific practices & data integrity are implemented in daily scientific activities,
• Ensure timely data collection, & reporting (including participation to internal/external scientific documents) in area of responsibility
• Demonstrates knowledge of the key research activities and good lab practices
• Takes appropriate actions to resolve issues in area of responsibility affecting research strategy and progress

Why you?Basic Qualifications:Knowledge/ Education / Previous Experience Required

• PhD in Life Sciences with 3+ years of postdoctoral and/or job-related experience, or equivalent acquired through professional experience
• Wide expertise in Protein Biophysics with a broad understanding of protein structure (e.g. X-ray crystallography, cryo-electron microscopy, structural mass spectrometry, single molecule dynamics) and biophysical characterization (protein-protein interaction, protein stability) AND/OR structure-based rational design (Alphafold, Rosetta Suite, MOE, Pymol, Phylogeny analysis, …); willingness to become proficient in both
• Additional experience in vaccine product development and/or recombinant protein expression and/or immunology and/or microbiology is an asset.

Job-Related Experience

• Demonstrated ability to lead a research or development project within the area of expertise.
• Experience in managing scientific team
• Capability to lead projects and implement strategies within a complex matrix organization

​Preferred Qualifications:

• Understand & implement processes specific to the vaccine R&D and to GSK with minimal bureaucracy and a focus on efficiency
• Understands function operating procedures and/or internal policies required to maintain quality standards and to protect GSK intellectual property
• Fluent in English, oral and writing, French is an asset
• Good communication skills, oral and writing
• Ability to present scientific data in front of large audience
• Good project scientific/technical strategy skills

If you have a disability and require assistance during the course of the selection process, you will have the opportunity to let us know what specific assistance you require in order to make suitable arrangements.Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK’s commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Expected salary

Location

Rixensart, Waals Brabant

Job date

Sun, 20 Oct 2024 01:09:35 GMT

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